Sure.
The first argument involves the gender gap.
Public Policy Polling found in late February that 51 percent of male GOP voters favored Trump, compared with just 39 percent of female Republicans: this was way before the new anti-Trump ads featuring his quotes.
Trump's gender gap would likely grow much wider in a general election.
Recently (last week in fact) ABC News published a poll that puts Clinton up 21 points among women over Trump in a head-to-head matchup.
This, however, would be a huge problem for Trump:
http://www.politico.com/magazine/story/2016/03/donald-trump-needs-7-of-10-white-guys-213699Trump would have to win 70 percent of white men voting in November to win, more than any Republican has won, even in landslide victories.
Mitt Romney was badly defeated among women voters. Trump would do even worse.
Barack Obama won women voters by 12 points over Romney in what Gallup called the largest gender gap in a presidential election since 1952. Women were the majority of voters that year, outnumbering men by a 55-45 margin, according to the Center for American Progress.The second argument should be pretty clear: Trump is wildly unpopular with Republican voters.
As of today, total votes cast so far:
TRUMP: 6,492,202
EVERYONE ELSE: 11,378,071
Exactly at this point in the voting process, four years ago we had:
ROMNEY: 6,018,802
EVERYONE ELSE: 5,365,337
DONALD TRUMP IS DISLIKED ALMOST 2:1 OVER ALL OF HIS RIVALS.
As if this wasn't enough, here is a very important third reason why Trump will lose the general election, the white collar vote:
http://thefederalist.com/2016/02/22/why-donald-trump-cant-win-the-white-house/