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Science & Alternative Science / Re: MEDICAL QUESTION: How does saline spray work?
« on: September 21, 2014, 01:33:46 AM »While it might theoretically be possible to accidentally overdose on Vitamin C, the logistics make it inconceivable. The LD50 in rats is 11.9g/kg. Assuming a similar level for humans you are talking about 550,000mg for a 50kg human, which is 275 of the highest dosage tablet generally seen on the market. Taking in to account that Vitamin C is water soluble, and excess quantities do not stay in your system for very long I think you would deliberately have to set out to OD on flinstones vitamins.
That's assuming that absorption of Vitamin C was 100%, which it isn't. If you could swallow 550,000 mg, the theoretical lethal dose, you would actually absorb very little of it.
Vitamins In Foods: Analysis, Bioavailability, and Stability
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"Beyond physiological intakes, absorption becomes progressively less efficient, falling from 75% of a single 1-g dose to 16% of a single 12-g dose (Table 19.2). This fall-off in efficiency occurs because absorption of high luminal concentrations of vitamin C takes place mainly by simple diffusion, and this passive movement proceeds at a very low rate."