I feel obligated to post about Ninja Scroll.
I think I watched Spirited Away once and maybe, like, Yugioh, or something, but other than that, I've never exposed myself to anime. I quite enjoyed Ninja Scroll, though. The story was ok, decent enough that I could keep watching, but basically, I just like the fight scenes and the vast range of characters. I think that animated characters allow for personality and characterization that are, most of the time, nearly impossible to reach with live action.
I could definitely watch more. If anybody has suggestions, shoot. Think action oriented, crazy villains, many characters, etc.